Search results for "scientific progress"
showing 9 items of 9 documents
Great Expectations: Principal Investigator and Trainee Perspectives on Hiring, Supervision, and Mentoring
2018
A functioning mentor–trainee relationship is of high importance in academia. Discrepancies in expectations between principal investigators (PIs) and trainees are a source of misunderstandings and conflicts, endangering scientific progress and career advancement. In this pilot study, we sought to explore the expectations of PIs and trainees, providing consensus data from physician‐scientists and junior researchers who attended an educational workshop, entitled “The EASL/AASLD Masterclass,” in December 2017. Twenty‐three Masterclass attendees, comprising nine trainees (four Ph.D. candidates, five postdoctoral researchers) and 14 PIs, responded to an online survey. Both parties were asked to s…
Not Entirely Reliable: Private Scientific Organizations and Risk Regulation – The Case of Electromagnetic Fields
2013
Private scientific organizations exert a great deal of influence in the regulation of some technological risks. The high level of expertise of their members is arguably a good reason for them to participate in making and monitoring risk regulations, in order to adjust these to scientific progress. Nevertheless, there are also sound reasons why governments shouldn’t uncritically follow the views expressed by such organizations. Taking the role played by the International Commission on Non–Ionizing Radiation Protection in the regulation of electromagnetic fields as an illustrative example, this paper shows that private scientific organizations such as these are structurally less well suited t…
Traditional Chinese medicines (TCMs) for molecular targeted therapies of tumours.
2009
Scientific progress in genetics, cell and molecular biology has greatly ameliorated our comprehensive understanding of the molecular mechanisms of neoplastic transformation and progression. The rapidly advancing identification of molecular targets in human cancers during the last decade has provided an excellent starting point for the development of novel therapeutics. A huge variety of potential molecular targets have been identified, many of which are already in the market for therapeutic purposes. It is now becoming possible to target pathways and/or molecules that are crucial in maintaining the malignant phenotype. Traditional Chinese medicine (TCM) is often considered as alternative or…
Constructive Dynamic Program Slicing Research
2010
Program slicing is a promising technique for providing automated support for various important software engineering activities. There exists hundreds of scientific studies on the theory of slicing. However, slicing is still not widely applied in software industry. Therefore, there is a need to survey and characterize the conducted research and to analyze what problems hinder progress. This paper answers to that need by providing a survey of constructive dynamic program slicing research focusing on publication series with high visibility. The survey identified 12 dynamic slicers related to which 12 aspects were studied. The analysis revealed many issues which can be seen both as concerns and…
IOC consensus statement on relative energy deficiency in sport (RED-S): 2018 update
2018
In 2014, the IOC published a consensus statement entitled ‘Beyond the Female Athlete Triad: Relative Energy Deficiency in Sport (RED-S)’. The syndrome of RED-S refers to ‘impaired physiological functioning caused by relative energy deficiency and includes, but is not limited to, impairments of metabolic rate, menstrual function, bone health, immunity, protein synthesis and cardiovascular health’. The aetiological factor of this syndrome is low energy availability (LEA).1 The publication of the RED-S consensus statement stimulated activity in the field of Female Athlete Triad science, including some initial controversy2 3 followed by numerous scientific publications addressing: 1. The health…
Closed Theories, Falsificationism and Non-Cumulative Progress
2020
It is argued that scientific progress occurs not with the cumulative growth of knowledge or when theories get closer to the truth but with discovering new domains and new theories that fit these domains. This horizontal view on the direction of scientific progress (in contrast to vertical, when we aim to get from here to the abstract and ephemeral truth) allows avoiding traditional objections posed by the incommensurability thesis and pessimistic induction, namely, that radical theory changes leave no room for progress. According to this perspective, the discovery of quantum mechanics as a new field of inquiry is a progress in itself, since this discovery had opened up a new distinctive dom…
Gardens on Canvas and Paper: Cataloguing Botanical Abundance in Late Medici Tuscany
2016
What is the purpose of portraying a branch from a pear tree in bloom and fruit, of listing hundreds of citrus varieties or of dissecting a huge truffle? When Cosimo III (1642–1723), the penultimate grand duke of the Medici dynasty, commissioned artists and botanists alike to create comprehensive visual and textual catalogues of Tuscan flora, aesthetics and curiosity seemed to go hand in hand with a demonstration of knowledge and prosperity. This article deals with the collection of botanical paintings by Bartolomeo Bimbi (1648–1730), housed in the Casino della Topaia close to the city of Florence, and with the mainly handwritten work of the grand ducal botanist Pier Antonio Micheli (1679–17…
Development of extracellular vesicle-based medicinal products: A position paper of the group “Extracellular Vesicle translatiOn to clinicaL perspecti…
2021
International audience; Extracellular vesicles (EV) are emergent therapeutic effectors that have reached clinical trial investigation. To translate EV-based therapeutic to clinic, the challenge is to demonstrate quality, safety, and efficacy, as required for any medicinal product. EV research translation into medicinal products is an exciting and challenging perspective. Recent papers, provide important guidance on regulatory aspects of pharmaceutical development, defining EVs for therapeutic applications and critical considerations for the development of potency tests. In addition, the ISEV Task Force on Regulatory Affairs and Clinical Use of EV-based Therapeutics as well as the Exosomes C…
A Case For a Study Quality Appraisal in Survey Studies in Psychology
2019
The lack of replication of key effects in psychology has highlighted some fundamental problems with reporting of research findings and methods used (Asendorpf et al., 2013; Open Science Collaboration, 2015). Problems with replication have been attributed to sources of bias such as questionable research practices like HARK-ing (Kerr, 1998) or p-hacking (Simmons et al., 2011). Another potential source of bias is lack of precision in the conduct and methods used in psychological research, which likely introduces systematic error into data collected with the potential to affect results. A related issue is lack of accuracy in reporting study methods and findings. There is, therefore, increased r…